The Ukrainian Biochemical Journal
ISSN 2409-4943

Journal archive > 2015 > N 1 January-February

NADH:UBIQUINONE REDUCTASE AND SUCCINATE DEHYDROGENASE ACTIVITY
IN THE LIVER OF RATS WITH ACETAMINOPHEN-INDUCED TOXIC HEPATITIS
ON THE BACKGROUND OF ALIMENTARY PROTEIN DEFICIENCY

G. P. Kopylchuk, O. M. Voloshchuk

Yuriy Fedkovych Chernivtsi National University, Institute of Biology, Chemistry and Life, Ukraine;

The ratio between the redox forms of the nicotinamide coenzymes and key enzymatic activity of the I and II respiratory chain complexes in the liver cells mitochondria of rats with acetaminophen-induced hepatitis under the conditions of alimentary deprivation of protein was studied. It was estimated, that under the conditions of acute acetaminophen-induced hepatitis of rats kept on a low-protein diet during 4 weeks a significant decrease of the NADH:ubiquinone reductase and succinate dehydrogenase activity with simultaneous increase of the ratio between redox forms of the nicotinamide coenzymes (NAD+/NADН) is observed compared to the same indices in the liver cells of animals with experimental hepatitis kept on the ration balanced by all nutrients. Results of research may become basic ones for the biochemical rationale for the approaches directed to the correction and elimination of the consequences­ of energy exchange in the toxic hepatitis, induced on the background of protein deficiency.

Key words: alimentary deprivation of protein, acetaminophen-induced hepatitis, NADH:ubiquinone reductase, the ratio between the redox forms of the nicotinamide coenzymes, succinate dehydrogenase.

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