The Ukrainian Biochemical Journal
ISSN 2409-4943

Journal archive > 2015 > N 1 January-February

ANTIOXIDANT PROPERTIES OF CLUSTER RHENIUM COMPOUNDS AND THEIR INFLUENCE
OF ERYTHROPOIESIS OF RATS WITH GUERIN CARCINOMA

Y. S. Voronkova1, S. O. Babiy1, L. V. Ivans’ka2, O. V. Shtemenko3, N. I. Shtemenko1

1Oles Honchar Dnipropetrovsk National University, Ukraine;
2Municipal Institution Dnipropetrovsk Polyprofile Clinical Hospital N 4
of Dnipropetrovsk Region Council, Clinic Diagnostic Laboratory, Ukraine;
3Ukrainian State University of Chemical Technology, Dnipropetrovsk;

Biochemical characteristics of kidneys, peripheral blood and bone marrow of rats in model of tumor growth under introduction of cisplatin and cis-tetrachlorodi-μ-isobutyratodirhenium(III), cis-Re2(i-C3H7COO)2Cl4 (I) have been investigated. It was shown that introduction of I alone and together with cisplatin led to decrease of biochemical markers of oxidation of lipids and proteins in tissue homogenates of the kidneys, change of enzyme activity in the urea and tissue homogenates of the kidneys, by a decrease of filtration function of kidneys. Introduction of nanoliposomal forms of the rhenium cluster compound led to a practically normal morphological picture of bone marrow and increase of the RBC (by 60%) with normalization of hematocrit counts, and decrease of quantities of destructed RBC (3.2 times) in comparison with the tumor-bearing animals. A tentative scheme of influence of cluster rhenium compound on erythropoiesis through regulation of synthesis of erythropoietin in kidneys has been proposed.

Key words: cluster rhenium compounds, cisplatin, erythropoiesis, bone marrow, kidney.

The original article in Ukrainian is available for download in PDF format.

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