The Ukrainian Biochemical Journal
 ISSN 2409-4943

Journal archive > 2015 > N 1 January-February

C60 FULLERENE PREVENTS GENOTOXIC EFFECTS OF DOXORUBICIN

IN HUMAN LYMPHOCYTES IN VITRO

K. S. Afanasieva1, S. V. Prylutska1, A. V. Lozovik1, K. I. Bogutska1, A. V. Sivolob1,
Yu. I. Prylutskyy1, U. Ritter2, P. Scharff2
1Taras Shevchenko National University of Kyiv, Ukraine;
е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.;
2Technical University of Ilmenau, Institute of Chemistry and Biotechnology, Ilmenau, Germany 

The self-ordering of C60  fullerene, doxorubicin and their mixture precipitated from aqueous solutions was investigated using atomic-force microscopy. The results suggest the complexation between the two compounds. The genotoxicity of doxorubicin in complex with C60  fullerene (С60+Dox) was evaluated in vitro with comet assay using human lymphocytes. The obtained results show that the C60  fullerene prevents the toxic effect of Dox in normal cells and, thus, С60+Dox complex might be proposed for biomedical application.

Key words: C60  fullerene, doxorubicin, human lymphocytes, genotoxicity, comet assay.

The original article in English is available for download in PDF format.

© The Ukrainian Biochemical Journal