Journal archive > 2014 > N 6 November-December
A. K. Gulevsky, N. N. Moisieieva, O. L. Gorina, J. S. Akhatova, A. A. Lavrik, A. V. Trifonova
The influence of a low-molecular fraction (below 5 kDa) from the cattle cord blood (CBF) on functional activity of phagocytes, human embryonic fibroblasts, mesenchymal stromal cells and BHK-21 clone 13/04 and PK-15 cells was studied. The low-molecular fraction added to culture medium increases the growth rate of cell cultures. The incubation of leukoconcentrate in the CBF-containing medium results in an increase in phagocytic indices of neutrophils in the presence of a phagocytosis inhibitor – sodium iodoacetate, leading to a significant increase in intracellular glucose content and alkaline phosphatase activity as compared to the control and the reference drug Actovegin®.
Key words: cord blood low-molecular fraction, Actovegin®, inhibitors of phagocytosis, leukocytes, glucose, alkaline phosphatase, human embryonic fibroblasts, mesenchymal stromal cells, BHK-21 clone 13/04, PK-15 cells.
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