ISSN 2409-4943
Ukr. Biochem. J.

Journal archive > 2014 > N 6 November-December

ACTIVITY OF TRYPSIN-LIKE ENZYMES AND GELATINASES IN RATS
WITH DOXORUBICIN CARDIOMYOPATHY

 Iu. А. Gordiienko1, Ya. V. Babets2, А. О. Kulinich1, А. І. Shevtsova1, G. О. Ushakova2

1SE Dnipropetrovsk Medical Academy of Health Ministry of Ukraine;
2Oles’ Honchar Dnipropetrovs’k National University, Ukraine;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Activity of trypsin-like enzymes (ATLE) and gelatinases A and B were studied in the blood plasma and extracts from cardiac muscle, cerebral cortex and cerebellum of rats with cardiomyopathy caused by anthracycline antibiotic doxorubicin against the background of preventive application of corvitin and α-ketoglutarate. ATLE significantly increased in blood plasma and extracts from cerebral cortex but decreased in extracts from cardiac muscle and cerebellum in doxorubicin cardiomyopathy (DCMP). In addition, a significant increase of activity of both gelatinases in plasma and tissue extracts was observed. Preventive administration of corvitin and α-ketoglutarate resulted in differently directed changes of activity of the above mentioned enzymes in heart and brain tissues. Obtained data confirm the hypothesis about activation of proteolysis under the influence of anthracycline antibiotics and testify to selective effect of corvitin and α-ketoglutarate on ATLE and gelatinases.

Key words: anthracycline antibiotics, cardiomyopathy, proteolysis, gelatinases A and B, trypsin-like enzymes, corvitin, α-ketoglutarate.

The original article in English is available for download in PDF format.

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