Journal archive > 2014 > N 3 May-June
N. V. Zaichko1, A. S. Olhovskiy1, A. V. Melnik1, P. A. Yurchenko1, A. S. Grigorieva2, N. F. Konahovich2
The influence of microelement preparation Esmin on hydrogen sulfide (H2S) levels, activity of H2S -producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated. In the process of aging the levels of H2S and activities of H2S-producing enzymes (cysteine aminotransferase, cystathionine-γ-lyase) are reduced in the myocardium; the pro-/antioxidant balance is destabilized (NADPH-oxidase activity is increased and thioredoxin reductase activity is decreased). Esmin administration effectively reduces age-related changes in the myocardium of old rats: increases H2S levels and activity of H2S-producing enzymes, restores pro-/antioxidant balance.
Key words: hydrogen sulfide, aging, myocardium, microelements, esmin.
The original article in Ukrainian is available for download in PDF format.
© The Ukrainian Biochemical Journal