INFLUENCE OF POLYMICROELEMENT PREPARATION ESMIN ON HYDROGEN SULFIDE LEVELS AND INDICES OF PRO- AND ANTIOXIDANT SYSTEM IN THE RAT MYOCARDIUM OF DIFFERENT AGE (N.V. Zaichko, A.S. Olhovskiy, A.V. Melnik, P.A. Yurchenko, A.S. Grigorieva, N.F. Konahovich)

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Journal archive > 2014 > N 3 May-June

INFLUENCE OF POLYMICROELEMENT PREPARATION ESMIN ON HYDROGEN

SULFIDE LEVELS AND INDICES OF PRO- AND ANTIOXIDANT SYSTEM

IN THE RAT MYOCARDIUM OF DIFFERENT AGE

N. V. Zaichko¹, A. S. Olhovskiy¹, A. V. Melnik¹, P. A. Yurchenko¹, A. S. Grigorieva², N. F. Konahovich²

¹Pirogov Vinnitsa National Medical University, Ukraine;

²SI Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine;

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The influence of microelement preparation Esmin on hydrogen sulfide (H₂S) levels, activity of H₂S -producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated. In the process of aging the levels of H₂S and activities of H₂S-producing enzymes (cysteine aminotransferase, cystathionine-γ-lyase) are reduced in the myocardium; the pro-/antioxidant balance is destabilized (NADPH-oxidase activity is increased and thioredoxin reductase activity is decreased). Esmin administration effectively reduces age-related changes in the myocardium of old rats: increases H₂S levels and activity of H₂S-producing enzymes, restores pro-/antioxidant balance.

Key words: hydrogen sulfide, aging, myocardium, microelements, esmin.

The original article in Ukrainian is available for download in PDF format.