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Journal archive > 2014 > N 3 May-June

INFLUENCE OF POLYMICROELEMENT PREPARATION ESMIN ON HYDROGEN
SULFIDE LEVELS AND INDICES OF PRO- AND ANTIOXIDANT SYSTEM
IN THE RAT MYOCARDIUM OF DIFFERENT AGE

N. V. Zaichko1, A. S. Olhovskiy1, A. V. Melnik1, P. A. Yurchenko1, A. S. Grigorieva2, N. F. Konahovich2

1Pirogov Vinnitsa National Medical University, Ukraine;
2SI Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine;

The influence of microelement preparation Esmin on hydrogen sulfide (H2S) levels, activity of H2S -producing enzymes and indices of pro-/antioxidant system in the myocardium of different age rats were investigated. In the process of aging the levels­ of H2S and activities of H2S-producing enzymes (cysteine aminotransferase, cystathionine-γ-lyase) are reduced in the myocardium; the pro-/antioxidant balance is destabilized (NADPH-oxidase activity is increased and thioredoxin reductase activity is decreased). Esmin administration effectively reduces age-related changes in the myocardium of old rats: increases H2S levels and activity of H2S-producing enzymes, restores pro-/antioxidant balance.

Key words: hydrogen sulfide, aging, myocardium, microelements, esmin.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal