N-STEAROYLETHANOLAMINE EFFECT ON THE LEVEL OF 11-HYDROXYCORTICOSTEROIDS, CYTOKINES IL-1β, IL-6 AND TNFα IN RATS WITH NONSPECIFIC INFLAMMATION CAUSED BY THERMAL BURN OF SKIN (A.D. Zhukov, A.G. Berdyshev, G.V. Kosiakova, V.M. Klimashevskiy...)

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Journal archive > 2014 > N 3 May-June

N-STEAROYLETHANOLAMINE EFFECT ON THE LEVEL OF 11-HYDROXYCORTICOSTEROIDS,

CYTOKINES IL-1β, IL-6 AND TNFα IN RATS WITH NONSPECIFIC INFLAMMATION

CAUSED BY THERMAL BURN OF SKIN

A. D. Zhukov, A. G. Berdyshev, G. V. Kosiakova, V. M. Klimashevskiy, T. M. Gorid’ko, O. F. Meged, N. M. Hula

Palladin Institute of Biochemistry, National Academy of Science of Ukraine, Kyiv;

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The mechanisms of anti-inflammatory action of saturated N-acylethanolamine – N-stearoylethanolamine (NSE) were investigated on the rat model of nonspecific inflammation (thermal burns of the skin). The results showed that the NSE application in a form of aqueous suspension (10 mg/ml) on the damaged skin area during 12 days significantly accelerated the healing process of burned wounds. NSE also prevented the increase of 11-hydroxycorticosteroids content in the blood of rats with burns. There was also found a significant decrease of cytokines (IL-1β, IL-6 and TNFα) levels under the NSE action. This way may be one of the mechanisms of NSE anti-inflammatory action.

Key words: N-stearoylethanolamine, 11-hydroxycorticosteroids, IL-1β, IL-6, TNFα, nonspecific inflammation, burn trauma of skin.

The original article in Ukrainian is available for download in PDF format.