Journal archive > 2014 > N 3 May-June
A. D. Zhukov, A. G. Berdyshev, G. V. Kosiakova, V. M. Klimashevskiy, T. M. Gorid’ko, O. F. Meged, N. M. Hula
The mechanisms of anti-inflammatory action of saturated N-acylethanolamine – N-stearoylethanolamine (NSE) were investigated on the rat model of nonspecific inflammation (thermal burns of the skin). The results showed that the NSE application in a form of aqueous suspension (10 mg/ml) on the damaged skin area during 12 days significantly accelerated the healing process of burned wounds. NSE also prevented the increase of 11-hydroxycorticosteroids content in the blood of rats with burns. There was also found a significant decrease of cytokines (IL-1β, IL-6 and TNFα) levels under the NSE action. This way may be one of the mechanisms of NSE anti-inflammatory action.
Key words: N-stearoylethanolamine, 11-hydroxycorticosteroids, IL-1β, IL-6, TNFα, nonspecific inflammation, burn trauma of skin.
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