NICOTINIC ACETYLCHOLINE RECEPTORS: SPECIFIC ANTIBODIES AND FUNCTIONS IN HUMORAL IMMUNITY
M. V. Skok, L. M. Koval, O. Yu. Lykhmus, O. M. Kalashnyk, G. L. Gergalova, S. V. Komisarenko
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels initially discovered in muscles and neurons and further found in many non-excitable cells. The present review summarizes the results of studies performed in the Department of Molecular Immunology during the last decade and concerning the structure and functions of nAChRs in B lymphocytes and in mitochondria, as well as the role of nAChR-specific antibodies in the development of neurodegenerative disorders like Alzheimer disease.
Key words: nicotinic acetylcholine receptors, B lymphocytes, mitochondria, antibodies, Alzheimer’s disease.
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