title en

Journal archive > 2013 > N 4 July-August

CORRELATION BETWEEN BASE CONCENTRATION OF C-REACTIVE PROTEIN IN THE BLOOD,
LEVELS OF SERUM ANTIENDOTOXIN ANTIBODIES AND ENDOTOXIN-BINDING CAPACITY
OF MONOCYTES AND GRANULOCYTES OF HEALTHY PEOPLE

A. I. Gordienko

State Institution S. I. Georgievsky Crimea State Medical University, Simferopol, Ukraine;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

The associative links between base concentration of C-reactive protein (hsCRP), levels of serum antiendotoxin antibodies of different classes and endotoxin-binding capacity of monocytes and granulocytes of healthy volunteers were investigated­ by cluster analysis. In the group of healthy volunteers with increased base concentration of hsCRP in blood the levels of serum antiendotoxin antibodies of different  classes and endotoxin-binding capacity of monocytes and granulocytes were reduced. Thus, the disbalance of detoxification and clearance of  endotoxin by humoral and cellular mechanisms can be one of the possible causes of development of low intensity inflammation and increase of hsCRP concentration in blood.

Key words: endotoxin, antibodies, receptor for endotoxin, C-reactive protein.

The original article in Russian is available for download in PDF format.

© The Ukrainian Biochemical Journal