DISTRIBUTION OF 5-FLUOROURACIL BETWEEN LYMPHOCYTES AND BLOOD PLASMA
M. A. Stashkevych, E. V. Khomutov, O. P. Shatova, Yu. V. Dumanskiy, I. I. Zinkovych
M. Gorky Donetsk National Medical University, Ukraine;
In blood plasma of 8 healthy volunteers with resuspended lymphocytes incubated with 5-fluorouracil (5-FU) the drug distribution between cells and liquid was assessed by means of HPLC. Rapid accumulation of 5-FU in lymphocytes was proved (the drug concentration on the 3-rd minute is 2.5-fold higher than in plasma) as well as the absence of temporal changes of 5-FU content both in lymphocytes and blood plasma during 30 minutes of experiment.
Key words: 5-fluorouracil, lymphocytes, plasma, endolymphatic administration.
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