K. S. Andreichenko1, S. V. Prylutska1, K. O. Medynska1, K. I. Bogutska1, N. E. Nurishchenko1, Yu. I. Prylutskyy1*, U. Ritter2, P. Scharff2
Joint Ukrainian-German Center on Nanobiotechnology
1Taras Shevchenko National University of Kyiv, Ukraine;
2Technical University of Ilmenau, Institute of Chemistry
and Biotechnology, Germany
Creation of new biocompatible nanomaterials, which can exhibit the specific biological effects, is an important complex problem that requires the use of last accomplishments of biotechnology. The effect of pristine water-soluble fullerene C60 on ATPase activity and superprecipitation reaction of rabbit skeletal muscle natural actomyosin has been revealed, namely an increase of actomyosin superprecipitation and Мg2+, Са2+- and K+-ATPase activity by fullerene was investigated. We conclude that this finding offers a real possibility for the regulation of contraction-relaxation of skeletal muscle with fullerene C60.
Key words: fullerene C60, skeletal muscle natural actomyosin, ATPase activity, superprecipitation, atomic force microscopy, molecular docking.
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© The Ukrainian Biochemical Journal