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Journal archive > 2013 > N 2 March-April

MECHANISM OF HEPATOPROTECTIVE ACTION OF METHIONINE
AND COMPOSITION «METOVITAN» AGAINST A BACKGROUND
OF ANTITUBERCULOSIS DRUGS ADMINISTRATION TO RATS

S. I. Anisimova1, G. V. Donchenko2, Yu. M. Parkhomenko2, V. M. Kovalenko1

1SI Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, Kyiv;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition «Metovitan» given with anti-TB drugs provided a correction of these abnormalities, that is evidenced by modulation of the level of CYP3A2, CYP2C23, CYP2E1 gene expression and antioxidant activity, inhibition of lipid peroxidation. «Metovitan» normalizes the enzymatic activity and content of total billirubin in the blood serum, shows high hepatoprotective properties, exceeding the efficiency of methionine.

Key words: hepatotoxicity, cytochrome P-450, CYP3A2, CYP2С23, CYP2E1, antituberculosis drugs, methionine, «Metovitan».

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal