S. I. Anisimova1, G. V. Donchenko2, Yu. M. Parkhomenko2, V. M. Kovalenko1
1SI Institute of Pharmacology and Toxicology, National Academy of Medical Sciences of Ukraine, Kyiv;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Oral administration of antituberculosis drugs to rats for 60 days in doses that are equivalent to clinical ones, causes changes in mRNA levels expression of liver cytochrome P-450 isoforms CYP3A2, CYP2C23, CYP2E1 and pro- and antioxidant state. Experimental composition «Metovitan» given with anti-TB drugs provided a correction of these abnormalities, that is evidenced by modulation of the level of CYP3A2, CYP2C23, CYP2E1 gene expression and antioxidant activity, inhibition of lipid peroxidation. «Metovitan» normalizes the enzymatic activity and content of total billirubin in the blood serum, shows high hepatoprotective properties, exceeding the efficiency of methionine.
Key words: hepatotoxicity, cytochrome P-450, CYP3A2, CYP2С23, CYP2E1, antituberculosis drugs, methionine, «Metovitan».
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© The Ukrainian Biochemical Journal