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Journal archive > 2013 > N 2 March-April

STRESS-RESPONSIVE SYSTEMS IN RAT PANCREAS UPON LONG-TERM GASTRIC
HYPOCHLORHYDRIA AND ADMINISTRATION OF MULTIPROBIOTIC «SYMBITER®»

K. O. Dvorshchenko, S. Ye. Vakal, A. S. Dranitsina, S. A. Senin, L. I. Ostapchenko

Taras Shevchenko National University of Kyiv, Ukraine;
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The intensity of free-radical processes upon long-term omeprazole-induced hypoacidity in the rat pancreas was investigated. Significant violation of oxidative-antioxidative balance in pancreatic tissue upon gastric hypochlorhydria was established: overproduction of superoxide anion, quantitative changes of lipid functional groups, increased level of lipid peroxidation products, augmentation of xanthine oxidase, superoxide dismutase and glutathione transferase activity, as well as depletion of catalase, glutathione peroxidase activity and reduced glutathione content. The inflected expression of Cckbr gene in the rat pancreas upon these conditions was also observed, thus suggesting an increased risk of pathological changes development in the gland. Abovementioned parameters were only partially restored to control values in the case of simultaneous administration of multiprobiotic «Symbiter®» with omeprazole, thus indicating the ability of this preparation to efficiently counteract the development of oxidative damages in pancrea­tic tissues upon long-term hypoacidic conditions.

Key words: hypochlorhydria, pancreas, superoxide anion, lipid peroxidation, antioxidant system, gene expression, probiotics.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal