EFFECT OF ANTICONVULSANTS ON THE NITRIC OXIDE SYSTEM
L. A. Gromov1, I. F. Belenichev2, L. G. Gonchar-Cherdakli1, G. A. Zhernovaja2
The effect of phenobarbital, carbamazepine, valproate sodium, depakine, topiramate and lamotrigine on the content of NO and NO-synthase activity in white rat brain tissues has been studied. It was established that the action of carbamazepine, valproate sodium, topiramate and lamotrigine decreases the activity of NO-synthase and the level of NO in the brain tissues. The amount of NO does not change while NO-synthase activity increases with the introduction of phenobarbital. The involvement of nitric oxide in the mechanism of action of the studied anticonvulsant drugs is discussed.
Key words: anticonvulsants, nitric oxide, NO-synthase.
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