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Journal archive > 2012 > N 6 November-December

ALDEHYDE REDUCTASE ACTIVITY AND BLOOD ALDO-KETO REDUCTASE SPECTRUM
IN ADOLESCENTS WITH NEUROENDOCRINE OBESITY

D. K. Kulieshova1, V. V. Davydov1, V. M. Shvets2

1Institute of Children and Adolescents Health Care, National Academy of Medical Sciences of Ukraine, Kharkiv;
2Zaporozhye State Medical University, Ukraine;
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Investigation of aldehyde-reductase activity and blood aldo-keto reductase spectrum has been performed in 13-15 and 16-18-years old adolescents with obesity to clear up the mechanisms of neuroendocrine obesity at the age of puberty. It has been established that basal aldehyde reductase activity and blood aldo-keto reductase spectrum of healthy adolescents in early puberty do not differ from those of healthy adolescents in late puberty. A decreased aldehyde reductase activity and some alterations in blood aldo-keto reductase spectrum have been observed in late puberty in adolescents with neuroendocrine obesity. In adolescents with obesity there have been registered some changes in blood aldo-keto reductase spectrum which are not accompanied by any alterations in its aldehyde reductase activity. The results obtained suggest that certain prerequisites are formed in late puberty to complicate the course of neuroendocrine obesity.

Key words: pubertal age, neuroendocrine obesity, aldo-keto reductases.

The original article in Russian is available for download in PDF format.

© The Ukrainian Biochemical Journal