ROLE OF PLASMINOGEN/PLASMIN IN FUNCTIONAL ACTIVITY OF BLOOD CELLS
D. D. Zhernossekov, E. I. Yusova, T. V. Grinenko
The article deals with the data concerning structural peculiarities of plasminogen/plasmin molecule, which define the specificity of intermolecular interactions and provide the variety of its biological functions. The main principles of the modern classification of plasminogen receptors and factors, which modulate their expression, have been presented. We have considered the mechanisms regulating both plasmin formation and activity on the surface of cells, fibrin and proteins of extracellular matrix. The data of previous investigators and our own results, concerning the influence of plasminogen/plasmin on platelet aggregation induced by different agonists, have been summarized. The participation of plasminogen/plasmin in atherogenesis and angiogenesis mediated by endotheliocyte receptors has been discussed. Special attention was given to plasminogen/plasmin pro-inflammatory function, which is realized by regulatory processes of activation, secretion, migration and apoptosis of monocytes and macrophages.
Key words: plasminogen, plasmin, lysine-binding sites of kringle domains, plasminogen receptors, blood cells, platelet aggregation, cell signaling, angiogenesis, inflammation.
The original article in Russian is available for download in PDF format.
© The Ukrainian Biochemical Journal