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Journal archive > 2012 > N 3 May-June

AVIDITY AND COMPETITIVE INHIBITION OF BINDING NATIVE AND CHAOTROPICALLY MODIFIED
IMMUNOGLOBULINS WITH PROTEIN AND GLYCOLIPID ANTIGENS

N. V. Khimich, A. I. Gоrdienko

State Institution S. I. Georgievsky Crimea State Medical University, Simferopol, Ukraine;
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It is established, that native and chaotropically modified immunoglobulins essentially differ by avidity and character of competitive inhibition of binding with protein (оvalbumin), glycolipid (lipopolysaccharides) antigens and native double-string DNA. Apparently, it is connected with structural and functional distinctions of their antigen-binding centres.

Key words: polyreactive immunoglobulins, native antibody, lipopolysaccharides, avidity, competitive inhibition of binding with antibodies.

The original article in Russian is available for download in PDF format.

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