THE EFFECT OF AGMATINE ON L-ARGININE METABOLISM IN ERYTHROCYTES UNDER STREPTOZOTOCIN-INDUCED DIABETES IN RATS (I.V. Ferents, I.V. Brodyak, M.Ya. Lyuta, V.A. Burda, A.M. Fedorovych, N.O. Sybirna)

title en

Journal archive > 2012 > N 3 May-June

THE EFFECT OF AGMATINE ON L-ARGININE METABOLISM IN ERYTHROCYTES

UNDER STREPTOZOTOCIN-INDUCED DIABETES IN RATS

I. V. Ferents, I. V. Brodyak, M. Ya. Lyuta, V. A. Burda, A. M. Fedorovych, N. O. Sybirna

Ivan Franko National University of Lviv, Ukraine;

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

The effects of agmatine on oxidative and non-oxidative metabolic pathways of L-arginine were investigated both in plasma and erythrocytes under experimental diabetes mellitus. It was indicated, that agmatine prevents the development of oxidative-nitrosative stress in diabetic rats. After treatment of animals by agmatine NO-synthase methabolic pathway of L-arginine is depressed whereas arginase one increases in erythrocytes of rats with experimental diabetes mellitus.

Key words: experimental diabetes mellitus, agmatine, plasma, erythrocyte, NO-synthase, nitrite, nitrate, arginase, ornitine.

The original article in Ukrainian is available for download in PDF format.