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Journal archive > 2012 > N 3 May-June

THE EFFECT OF AGMATINE ON L-ARGININE METABOLISM IN ERYTHROCYTES
UNDER STREPTOZOTOCIN-INDUCED DIABETES IN RATS

I. V. Ferents, I. V. Brodyak, M. Ya. Lyuta, V. A. Burda, A. M. Fedorovych, N. O. Sybirna

Ivan Franko National University of Lviv, Ukraine;
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The effects of agmatine on oxidative and non-oxidative metabolic pathways of L-arginine were investigated both in plasma and erythrocytes under experimental diabetes mellitus. It was indicated, that agmatine prevents the development of oxidative-nitrosative stress in diabetic rats. After treatment of animals by agmatine NO-synthase methabolic pathway of L-arginine is depressed whereas arginase one increases in erythrocytes of rats with experimental diabetes mellitus.

Key words: experimental diabetes mellitus, agmatine, plasma, erythrocyte, NO-synthase, nitrite, nitrate, arginase, ornitine.

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© The Ukrainian Biochemical Journal