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Journal archive > 2012 > N 3 May-June

CHANGES OF THE STATE OF RAT KIDNEYS UNDER GUERIN CARCINOMA
DEVELOPMENT AND USE OF CYTOSTATICS

S. A. Babiy1, T. F. Loskutova2, N. I. Shtemenko1

1Oles Gonchar Dnipropetrovsk National University, Ukraine;
2Dnipropetrovsk State Medical Acadamy, Ukraine;

It was shown that development of the Guerin carcinoma and introduction of cisplatin led to the damage of the kidneys of rats that was confirmed by a relative increase of weight, proteinuria, change of ?-glutamyl transpeptidase and lactate dehydrogenase activity in the urea and tissue homogenates of the kidneys, by a decrease of relative reabsorption and glomerular filtration. Introduction of nanoliposomal forms of the rhenium cluster compounds led to normalization of above mentioned diagnostic indexes and to reduction of the toxic cisplatin influence that was confirmed by biochemical and morphological investigations.

Key words: kidneys, cluster rhenium compounds, cisplatin, antitumor compounds, nephrotoxicity.

The original article in Ukrainian is available for download in PDF format.

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