ACTIVATION OF THE PHOSPHATIDYLINOSITOL-3?-KINASE PATHWAY WITH LECTIN-INDUCED SIGNAL THROUGH
SIALO-CONTAINING GLYCOPROTEINS OF LEUKOCYTE MEMBRANES UNDER TYPE 1 DIABETES MELLITUS
1Ivan Franko National University of Lviv, Ukraine;
2Institute of Cell Biology, National of Academy of Sciences of Ukraine, Lviv;
The influence of wortmannin and sialospecific lectins on the translocation of p85? regulatory subunit of phosphatidylinositol-3?-kinase (PI-3?-kinase) between membrane and cytosolic fractions of the mononuclear and polymorphonuclear leukocytes in healthy donors and patients with type 1 diabetes mellitus (DM) was investigated. It was found out that under type 1 DM PI-3?-kinase takes active part in the transduction of lectin-induced signal through membrane glycoprotein receptors that contain terminal sialic acids linked to subterminal carbohydrate residues with (?2?6) glycosidic bond.
Key words: mononuclear leukocytes, polymorphonuclear leukocytes, sialoglycoprotein receptors, sialospecific lectins, phosphatidylinositol-3?-kinase, wortmannin, type 1 diabetes mellitus.
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© The Ukrainian Biochemical Journal