ANTIOXIDANT SYSTEM ACTIVATION IN RATS WITH EXPERIMENTAL CIRRHOSIS
AFTER INJECTION OF CRYOPRESERVED FETAL LIVER CELLS
1Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, Kharkiv;
2Research Institute of Biology, V. N. Karazin Kharkiv National University, Ukraine;
The possibility to recover the antioxidant system in rats with experimental liver cirrhosis (LC) after allo- and xenotransplantation of cryopreserved fetal liver cells (FLC) was investigated. It was shown that the content of lipid peroxidation products in the blood serum of animals with LC four weeks after FLC transplantation decreased significantly as compared to control group. Such changes were accompanied by a significant increase of catalase (CAT), glutathione reductase (GR), Se-dependent glutathione peroxidase (GP) activity in the liver and total anti-oxidative activity (AOA) of blood.
Obtained results demonstrate that the main direction of FLC effects in animals with LC agree with that we observed previously in other experimental models (partial hepatectomy, chronic alcohol poisoning and hypercholesterolemia). In conclusion, cell therapy may be considered as the universal method for correction of disorders in regulation of free-radical processes in various experimental pathologies.
Key words: antioxidant system, experimental cirrhosis, fetal liver cells, transplantation.
The original article in Ukrainian is available for download in PDF format.
© The Ukrainian Biochemical Journal