Journal archive  2010  #3 May-June

THE INFLUENCE OF ?-CAROTENE AND CAROTENE PRODUCING YEAST Phaffia rhodozyma

ON OXIDATIVE STRESS IN RATS TREATED WITH TETRACHLOROMETHANE

M. I. Simonova, N. I. Boretska, M. V. Kaminska, H. I. Nechay, A. V. Kоlisnyk, V. V. Vlizlo

Institute of Animal Biology NAASU, Lviv;
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Summary

Supplementation of rats’ diet with ?-carotene or biomass of carotene producing yeast Phaffia rhodozyma caused a decrease of aminotransferases in the blood serum as well as a decrease of lipid peroxidation products and protein carbonil groups in the liver, brain and myocardium tissues of animals treated with tetrachloromethane. When compared to the control group the activity of superoxide dismutase, catalase and glutathione peroxidase in the liver of carotene fed rats were respectively 1.6, 2.2, and 1.5-fold higher. Thus, these supplements to standard diet slow down development of tetrachlorometane mediated oxidative stress in rats.

Key words: ?-carotene, yeast Phaffia rhodozyma, oxidative stress, tetrachloromethane.

The original article in Ukrainian is available for download in PDF format.