DEPENDENCE OF BIOLOGICAL ACTIVITY OF N-ACYL DERIVATES
OF 6-ALKOXY-2-METHYL-4-MERCAPTOQUINOLINE ON THE NATURE
OF SUBSTITUENTS IN THE POSITION 6 OF THE HETEROCYCLE
1Zaporizhia State University, Ukraine;
2Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kyiv;
The influence of substituents in the sixth position of N-acyl derivatives of 2-methyl-4-mercaptoquinoline on hepatoprotective and antioxidant effect was investigated. It was also determined that alcoxy-derivatives show hepatoprotective, antiradical, antioxidant activity and can act as preventive antioxidants. Introduction of the ethoxy-group into the sixth position of azoheterocycle potentiates activity. Symbasis of intensities of hepatoprotective and antioxidant actions of the investigated compounds was proved.
Key words: N-acyl derivatives of 2-methyl-4-mercaptoquinoline, hepatoprotective activity, antioxidant activity.
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