Journal archive  2010  #3 May-June

DEPENDENCE OF BIOLOGICAL ACTIVITY OF N-ACYL DERIVATES

OF 6-ALKOXY-2-METHYL-4-MERCAPTOQUINOLINE ON THE NATURE

OF SUBSTITUENTS IN THE POSITION 6 OF THE HETEROCYCLE

I. B. Labenska1, G. A. Shapoval2, O. S. Kruglyak2, L. A. Omeljanchik1, O. A. Brazhko1, M. P. Zavgorodny1

1Zaporizhia State University, Ukraine;
2Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kyiv;
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Summary

The influence of substituents in the sixth position of N-acyl derivatives of 2-methyl-4-mercaptoquinoline on hepatoprotective and antioxidant effect was investigated. It was also determined that alcoxy-derivatives show hepatoprotective, antiradical, antioxidant activity and can act as preventive antioxidants. Introduction of the ethoxy-group into the sixth position of azoheterocycle potentiates activity. Symbasis of intensities of hepatoprotective and antioxidant actions of the investigated compounds was proved.

Key words: N-acyl derivatives of 2-methyl-4-mercaptoquinoline, hepatoprotective activity, antioxidant activity.

The original article in Ukrainian is available for download in PDF format.