THE MODULATION OF N-STEAROYLETHANOLAMINE EFFECT OF 17?-ESTRADIOL
IN THE ORGANISM OF MALE RATS
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
The influence of N-stearoylethanolamine (NSE) on total 11-hydroxycorticosteroids (11-HCS) and testosterone level in the blood of male rats in normal conditions and under the action of 17?-estradiol (400 mkg/kg of body weight during 3 days) was studied. It was shown that NSE administration per os (50 mg/kg of body weight during 7 days) to intact animals did not change the level of 11-HCS and of testosterone. The administration of NSE to estrogenized male rats decreased the elevated level of 11-HCS and normalized the amount of testosterone in blood. The correction of alterated weight of adenohypophysis and testis of estrogenized male rats compared to control can be a direct evidence of NSE-mediated modulation of the effect on hypothalamic-pituitary hormone system. The effect of NSE in the testis of estrogenized male rats inhibited the process of lipid peroxidation, caused the decrease of the amount of thiobarbituric acid reactive substances and increased the activity of superoxide dismutase and catalase. The NSE showed more expressed antioxidative effect compared to vitamin E. Taking into consideration all above mentioned data we suggested that NSE administration to male rats protected Leydig cells from damage under the increase of estrogen level.
Key words: N-stearoylethanolamine, 17?-estradiol, testis, testosterone, 11-hydroxycorticosteroids, adenohypophysis, lipid peroxidation, antioxidative enzymes.
The original article in Ukrainian is available for download in PDF format.