THE ROLE OF HYPOXIA-INDUCIBLE PROTEINES FAMILY (HIF)
IN THE REGULATION OF CELLS PHYSIOLOGIC RESPONSES TO HYPOXIA
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
The review is devoted to the role of hypoxia-inducible factors (HIF) in the regulation of oxygen-dependent gene signalling. Structural features of HIF ? and ? subunits as well as involvement of hydroxylation in the regulation of HIF stability and activity are described. Special attention is given to the role of phosphorylation and other post-translational modifications in the regulation of HIF expression and activity. The survey considers the involvement of hormones, cytokines and growth factors in HIF stimulation under normoxia. HIF target genes and promotor/enhancer sequences, responsible for oxygen-dependent gene regulation, are also described.
Key words: hypoxia, hypoxia inducible factors, hydroxylation, phosphorylation.
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