Journal archive  2010  #4 July-August

PKD FAMILY PROTEIN KINASES AS A POTENTIAL OBJECT
OF TRANSLATIONAL RESEARCH IN ONCOLOGY

S. V. Mikhalap, M. Yu. Shabelnik, S. P. Sidorenko

Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology,
National Academy of Sciences of Ukraine, Kyiv;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Recent scientific research demonstrates that protein kinases of PKD family affect biological features of normal and malignant cells. Differential expression of PKD genes was found in tumors of different histogenesis. These protein kinases could be activated by growth factors, antigen stimulation, and oxidative stress, the processes that usually can be observed during tumor progression. PKD regulate cell-cell contacts by affecting cell adhesion. PKD are involved in the regulation of cell proliferation and apoptosis, and also participate in epigenetic regulation of gene expression. That is why studies of differential expression and activity of PKD1, PKD2 and PKD3 in the context of tumor spreading and prognosis could be the perspective subject of translational research in oncology. This will contribute to the development of new approaches to differential diagnostics of tumor and target therapy, and also reveal prognostic factors for the prediction of clinical outcome.

Key words: PKD family protein kinases, oncology, signalling cascades, cell adhesion, translational research.

The original article in Ukrainian is available for download in PDF format.