THE INFLUENCE OF N-, S-CONTAINING CHINASOLONE DERIVATIVES (NC-224) ON THE BIOCHEMICAL
AND PHYSICO-CHEMICAL PARAMETERS OF MEMBRANE ENDOPLASMATIC RETICULUM AND NUCLEAR CHROMATINE
FRACTIONS OF RATS LIVER CELLS IN CONDITIONS OF ITS INJURY BY TETRACHLOROMETHANE
1SI Intitute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv;
2Zaporizhia State Medical University, Ukraine;
Using biochemical and physicochemical methods of investigation in vivo, the effect of the substance NC-224, N-,S-chinasolone-derivative, on the lipoperoxidation activity in rat liver endoplasmatic reticulum membranes and nuclear chromatin fractions under tetrachloromethane intoxication have been studied. It was shown that NC-224 has pronounced antioxidant activity which is the biochemical basis of the substance membrane- and genome-protective effects and its ability to restore physicochemical properties of the surface and hydrophobic zones of hepatocyte membranes and structural parameter nuclear chromatin fractions in the conditions of chemical liver injury.
Key words: transcriptionally active chromatin, repressed chromatin, membrane endoplasmatic reticulum, tetrachloromethane, lipoperoxidation, fluorescence probe, chinazolone derivate, antioxidante.
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