THE STATE OF LIPID PEROXIDATION AND ANTIOXIDANT PROTECTION SYSTEM IN PARIETAL CELLS UNDER EXPERIMENTAL CHRONIC ATROPHIC GASTRITIS DEVELOPMENT
Taras Shevchenko Kyiv National University, Ukraine;
The lipid peroxidation state and the system functioning of antioxidant protection in parietal cells under rat chronic atrophic gastritis development was investigated. It was detected that the compensatory increase of superoxide dismutase and catalase activity did not affect the lipoperoxidation process and this resulted in accumulation of toxic TBA reactive substances and diene conjugates during the whole stages of the experimental pathology development. It was shown that the reserved power of the glutathione antioxidant system is sufficient to provide adoptable response in the acute period of the disease owing to increasing intracellular found of the reduced glutathione, but it is insufficient to prevent its decreasing in parietal cells in case of the chronic atrophic gastritis development.
Our findings suggest that glutathione system is involved in processes of gastric atrophy. The obtained results testify about considerable system dysfunctions of lipid peroxidation and the antioxidant protection in processes of the rat experimental atrophic gastritis development.
Key words: chronic atrophic gastritis, parietal cell, lipid peroxidation, glutathione, glutathione-related enzymes, glucose-6-phosphate dehydrogenase.
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