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Journal archive > 2010 > N 2 March-April

B-, H- AND L-CATHEPSIN-LIKE ACTIVITY IN BLOOD PLASMA OF?PATIENTS WITH DISEASES
OF?THYROID, PARATHYROID AND ADRENAL GLANDS

O. V. Kalinichenko, T. M. Myshunina, M.?D.?Tronko

State Institution «Komissarenko Institute of Endocrinology and Metabolism,
Academy of Medical Sciences of Ukraine», Kyiv;
e-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.

B-, H- and L-catepsine-like activity regarding­ N?-benzoyl-D,L-arginine-4-nitroanilide, L-leucine-4-nitroanilide and azocasein was studied in the blood plasma of patients with different diseases of thyroid, parathyroid and adrenal glands. It has been shown that the high H- catepsine-like activi­ty confirming the activation of blood catepsin H secretion accompanied by the tissue growth under any pathology took place in the blood plasma of patients with all the above diseases. High B- catep­sine-like activity in the blood plasma of patients with thyroid diseases was exceptionally fixed under the nodular forms of thyroid pathology, while the character of changes in L catepsine-like activity under these diseases was not so natural. In diaseses of the adrenal glands the changes in the B- and L-catepsine-like activity were only shown in the blood plasma of patients with cerebral layer tumors but not the gland cortex: B-catepsine-like activi­ty increased in the blood plasma of patients with benign or malignant tumors, and L-catepsine-like activity decreased under benign tumor from chromaffin tissue. The established picture of changes in enzymatic activity in the blood plasma of patients does not allow to think that the determination of blood B- and L- catepsine-like  activity can be recommended for obtaining additional information at diagnosis thyroid diseases.

Key words: cysteinic cathepsins B, H, L, pathology of thyroid, parathyroid and adrenal glands, blood.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal