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Journal archive > 2010 > N 2 March-April

ADAPTATION OF ANTIOXIDATIVE SYSTEM IN RAT KIDNEYS UNDER VARYING LIGHT CONDITIONS
UNDER TETRACHLOROMETHANE INTOXICATION AND MELATONIN INFLUENCE

I. V. Matsiopa, N. P. Grygorieva, I.F.Meshchyshen

Bukovinian State Medical University, Chernivtsi;
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The influence of varying light conditions of the state of pro- and antioxidative systems in rat kidneys has been studied. The lowest level of free radical oxidation of lipids and proteins and the highest activity of catalase and glutathione peroxidase in the rat kidneys was established in case of maximal duration of the light day. Under different light conditions the increase of malonic aldehyde and oxidatively modified proteins in the rat kidneys in case of tetrachloromethane intoxication was shown as compared with the control. It was established, that melatonin introduction during 5 days in a doze of 3.0 mg/kg of body weight reduces the content of products of free radical oxidation of lipids and proteins and shows the normalizing effect on the indices of antioxidative system in rat kidneys.

Key words: light conditions, tetrachloromethane, melatonin, lipid and protein peroxidation, antioxidative system, kidneys.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal