Na+,K+-ATPase FUNCTIONING IN?POLARIZED CELLS
A. A. Kaplia1, V. S. Morozova2
1Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
2Lugansk Taras Shevchenko National University, Ukraine
The novel views on fundamental role of Na+,K+-AТPase in regulation of the polarized morphology of the epithelial cells, enzyme involvement in signal transduction, assembly of intermolecular signaling complexes have been reviewed. The modern state of researches are considered in detail, including: sorting specificity in polarized cells, Na+,K+-AТPase involvement in epithelial cell interactions, enzyme arrangement in combined structural and functional ensemble with adhesion and cytoskeleton proteins, their coordinated expression. The mechanisms of the Na+,K+-AТPase association with its molecular partners and the role of specific domains, motives and binding sites are analysed. The available data, including own researches indicate the Na+,K+-AТPase involvement in certain pathologies that develop with aberration of polarized epithelial phenotype, malignant growth in particular.
Key words: Na+,K+-AТPase, epithelium, intercellular interactions, protein partners, signal transduction, malignant growth.
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© The Ukrainian Biochemical Journal