title en

Journal archive > 2010 > N 1 January-February

INTERRELATION BETWEEN ANTIOXIDANT GEPATOPROTECTIVE ACTION OF SOME DERIVATIVES
OF MONOCHROMANES AND TRIMETHYLPHENOLS AND ENERGY STRUCTURAL
QUANTUM-CHEMICAL PARAMETERS

Yu. I. Gubskiy, G. G. Goriushko, V.P.Makovecky, N. V. Litvinova, O.?M.?Marchenko, O. M. Velichko, L.?P.?Babenko, V. V. Olar

SI Intitute of Pharmacology and Toxicology,
Academy of Medical Sciences of Ukraine, Kyiv;
е-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Energy and structural parameters of monochromanes and trimethylphenols derivatives have been chracterized through the employment of semiempirical methods of quantum chemistry. The correlation has been proved between antiradical, hepatoprotective properties of these compounds and energy and structural of their molecules that confirms the presence of relation between structure activity and electron-donor properties of the investigated monochromanes and trimethylphenols.

Key words: membranes, antioxidant, antiradical properties, molecular orbitals energy, monochromanes, trimethylphenols.

The original article in Ukrainian is available for download in PDF format.

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