O. Yu. Petrenko1, I. O. Sosimchyk1, D.? V.? Cherkashina1, O. A. Semenchenko1, V.P. Skulachev2
1Institute for Problems of Cryobiology and Cryomedicine, National Academy of Sciences of Ukraine, Kharkov;
2Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University;
The influence of mitochondria-targeted antioxidant 10-(6-plastoquinonyl)decyltriphenylphosphonium (SkQ1) different concentrations on respiratory parameters and lipid peroxidation process intensity in the rat liver after hypothermic storage was investigated. It was shown that cold storage of isolated liver during 18 h results in accumulation of TBA-active products, increase of intensity of Fe2+-ascorbate induced lipid peroxidation and depression of mitochondria functional activity. SkQ1 inhibits activation of free radical processes in a dose-dependent manner and it has a positive influence on energetic coupling in mitochondria.
Key words: SkQ1, mitochondrial antioxidant, liver hypothermic storage, respiratory activity, lipid peroxidation.
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