title en

Journal archive > 2009 > N 6 November-December

CYTOPLASMIC MEMBRANE PHOSPHOLIPID CONTENT AND PHOSPHOLIPASE C ACTIVITY
IN RAT EPITHELIAL CELL UNDER COLITIS-ASSOCIATED CARCINOGENESIS

O. V. Drobinska, O. O. Kravchenko, V. A.Kovaleva, O. Y. Artemenko, L.I.Ostapchenko

Taras Shevchenko Kyiv National University, Ukraine;
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The decrease of major cytoplasmic membrane phospholipids (phosphatidylcholine and phosphatidylethanolamine) content was established in mucosal epithelial cell under colon inflammation pathology – ulcerative colitis. It was shown that aforementioned changes were associated with the increase of phospholipids’ hydrolyzing enzyme?– phospholipase C activity and intracellular Ca2+ concentration enlargement. Carcinogenesis stimulation under inflammation was accompanied by phospholipase C activity increase when quantity of investigated phospholipids (phosphatidylcholine, phosphatidylinozytol, phosphatidylserine) separately decreased and cytoplasmic Ca2+ value normalization was established.

Key word: phospholipids, cytoplasmic membrane, phospholipase C, cytosolic Ca2+, colitis-associated carcinogenesis.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal