O. V. Drobinska, O. O. Kravchenko, V. A.Kovaleva, O. Y. Artemenko, L.I.Ostapchenko
Taras Shevchenko Kyiv National University, Ukraine;
The decrease of major cytoplasmic membrane phospholipids (phosphatidylcholine and phosphatidylethanolamine) content was established in mucosal epithelial cell under colon inflammation pathology – ulcerative colitis. It was shown that aforementioned changes were associated with the increase of phospholipids’ hydrolyzing enzyme?– phospholipase C activity and intracellular Ca2+ concentration enlargement. Carcinogenesis stimulation under inflammation was accompanied by phospholipase C activity increase when quantity of investigated phospholipids (phosphatidylcholine, phosphatidylinozytol, phosphatidylserine) separately decreased and cytoplasmic Ca2+ value normalization was established.
Key word: phospholipids, cytoplasmic membrane, phospholipase C, cytosolic Ca2+, colitis-associated carcinogenesis.
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