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Journal archive > 2009 > N 6 November-December

THE DISTURBANCE OF SPECTRUM OF MEMBRANE PROTEINS OF ERYTHROCYTES
UNDER TYPE 1 DIABETES MELLITUS

N. O. Sybirna, T. V. Buslyk

Ivan Franko Lviv National University, Department of Biochemistry, Ukraine;
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The research has shown substantial changes in the percentage correlation between plasmatic membrane proteins and erythrocyte cytoskeleton (?-spectrin, ?-spectrin, ankyrin, band 4.1) under type 1 diabetes mellitus. It has also established the difference in the content of erythrocyte membrane glycoproteins, i.e. band 3 proteins and glycopho­rine?A, in healthy donors and patients with diabetes. Thus the  content of glycophorine A decreased by 27%, while the content of band 3 protein increased by 23%. Under the pathology, changes in the structure of carbohydrate determinants of erythrocytes membrane glycoproteins were revealed by means of the lectin blot analysis. Type 1 diabetes mellitus is accompanied by an increase in the number of glyco­proteins with mannose-containing carbohydrate determinants complementary to Con?A and LCA, on the one hand, and a decrease in the number of glycoproteins with sialo- and galactose-containing oligosaccharides complementary to WGA and RCA lectins, on the other hand, on the erythrocyte membrane surface.

Key words: erythrocyte membranes, glycoproteins, type 1 diabetes mellitus.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal