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Journal archive > 2009 > N 5 September-October

EFFECT OF HOMOCYSTEINE ON THE STRUCTURE AND FUNCTIONS
OF?HUMAN PLACENTA TROPHOBLAST

O. P. Martsenyuk1,2, K. L. Romanets2, M. Yu. Obolenska1, B. Huppertz3

1Institute of Molecular Biology and Genetics, National Academy of Science of Ukraine, Kyiv;
2Taras Shevchenko Kyiv National University, Ukraine;
3Medical University of Graz, Department of Cell Biology, Histology and Embryology, Austria;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Elevated level of homocysteine in blood serum of pregnant women is the risk factor for placental malfunction and fetal abnormalities. Our study has shown the activation of apoptosis, inhibition of proliferation, destruction of placental trophoblast and activation of the transsulfuration pathway under elevated homocysteine level in the incubation medium in the range of 20-80 µМ. The activation of the transsulfuration pathway indicates that placenta may to some extent withstand elevated homocysteine level.

Key words: human placenta, homocysteine, folic acid, transsulfuration.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal