INFLUENCE OF PROTHROMBIN CLEAVAGE PRODUCTS ON PLATELETS ACTIVATION AND AGGREGATION (D.S. Korolova, V.O. Chernyshenko, O.V. Gornitskaya, T.M. Platonova)

title en

Journal archive > 2009 > N 5 September-October

INFLUENCE OF PROTHROMBIN CLEAVAGE PRODUCTS ON PLATELETS

ACTIVATION AND AGGREGATION

D. S. Korolova, V. O. Chernyshenko, O. V. Gornitskaya, T. M. Platonova

Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Meizothrombin efficiently activates mechanically triggered platelets and enhance collagen-, ADP- and adrenalin-induced aggregation of platelet-rich blood plasma. Thus, in clotting system activation zone meizothrombin is able to enhance process of involving platelets in clotformation. Prethrombin 1 inhibits collagen-, ADP- and adrenalin-induced aggregation of platelet-rich blood plasma and so regulates not only plasm but platelet hemostasis by reverse negative relation.

Key words: meizothrombin, prethrombin?1, thrombin, platelets.

The original article in Ukrainian is available for download in PDF format.