D. S. Korolova, V. O. Chernyshenko, O. V. Gornitskaya, T. M. Platonova
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Meizothrombin efficiently activates mechanically triggered platelets and enhance collagen-, ADP- and adrenalin-induced aggregation of platelet-rich blood plasma. Thus, in clotting system activation zone meizothrombin is able to enhance process of involving platelets in clotformation. Prethrombin 1 inhibits collagen-, ADP- and adrenalin-induced aggregation of platelet-rich blood plasma and so regulates not only plasm but platelet hemostasis by reverse negative relation.
Key words: meizothrombin, prethrombin?1, thrombin, platelets.
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