title ru

Journal archive > 2009 > N 3 May-June

BIOLOGICAL FEATURES OF IMMUNOGLOBULINS OF CLASS G
IN MICE FED FOR A LONG TIME WITH BRAIN OF CATTLE

M. R. Kozak1, V. V. Vlizlo1, Yu. Ya. Kit2, R. S. Stoika2

1Institute of Animal Biology, Ukrainian Academy of Agrarian Sciences, Lviv;
2Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

It was found that mice fed with brain of cattle or brain of cattle with a meat-bone flour (1?:?1), were capable of producing immunoglobulins which interacted with DNA, and protein and lipid fractions of mouse brain. These immunoproteins also induced death of cells of L1210 line of murine leukemia via apoptosis accompanied by changes in the animal level of proteins Bcl-2, p53 and procaspase 3. The potentials of using this experimental animal model for studying cytopathogenetic mechanisms of transmissible spongiform encephalopathies are discussed.

Key words: immunoglobulins, ration, cells, mouse, apoptosis.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal