M. R. Kozak1, V. V. Vlizlo1, Yu. Ya. Kit2, R. S. Stoika2
1Institute of Animal Biology, Ukrainian Academy of Agrarian Sciences, Lviv;
2Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv;
It was found that mice fed with brain of cattle or brain of cattle with a meat-bone flour (1?:?1), were capable of producing immunoglobulins which interacted with DNA, and protein and lipid fractions of mouse brain. These immunoproteins also induced death of cells of L1210 line of murine leukemia via apoptosis accompanied by changes in the animal level of proteins Bcl-2, p53 and procaspase 3. The potentials of using this experimental animal model for studying cytopathogenetic mechanisms of transmissible spongiform encephalopathies are discussed.
Key words: immunoglobulins, ration, cells, mouse, apoptosis.
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© The Ukrainian Biochemical Journal