L. I. Ostapchenko, О. V. Drobinska, V. О. Chaika, L. I. Bogun, О. V. Bogdanova, L. І. Коt, L. М. Gaida
The goal of the presented work was the research of signal transduction mechanism in the rat gastric parietal cells under stomach ulcer conditions. In these cells activation of adenylate cyclase (increase of cAMP level and proteinkinase A activity) and phosphoinositide (increases [Са2+]і; cGMP and phoshatidylinocitole levels; proteinkinase C, proteinkinase G, and calmodulin-dependent-proteinkinase activity) of signals pathway was shown. An increase of plasma membrane phospholipids (PC, PS, PE, PI, LPС) level was shown. Under conditions of influence of the stress factor the membran enzymes activity (H+,K+-ATPase, 5?-АМPase, Na+,K+-ATPase, Са2+,Mg2+-ATPase and H+,K+-ATPase) was considerably increased. The intensification of lipid peroxidation processes in rats was demonstrated.
Key words: parietal cells, stomach ulcer, proteinkinases, cAMP, cGMP, phospholipid, ROS, membrane-bound enzymes, [Са2+]і, Н+,K+-ATPase.
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