Journal archive > 2009 > N 2 March-April
Yu. V. Peretiatko, N. O. Sybirna
Arginine takes part in many metabolic cell processes. It is not only involved in the dynamic cycle of interconversion with prolin and glutamine but also serves as a precursor for protein, nitric oxide, creatine, polyamines, agmatine and urea synthesis. Particularities of arginase and NO-synthase pathways of L-arginine conversion under the X ray radiation in the leucocytes – radiosensitive cells of peripheral blood, under the per os administration of L-arginine and L-NAME (NG-nitro-L-arginine methyl ester) to rats were detected. It was shown that both L-arginine (arginase and NO-synthase main substrate) and L NAME (nonspecific inhibitor of NO-synthase) had a positive correct influence on the organism in case of decreasing of NO overproduction under the X-ray radiation.
Key words: arginase, L-arginine, leucocytes, nitric oxide, NO-synthase, plasma.
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