Journal archive > 2009 > N 2 March-April

PARTICULARITIES OF ARGINASE AND NO-SYNTHASE PATHWAYS OF L-ARGININE CONVERSION
IN THE LEUCOCYTES OF PERIPHERAL BLOOD UNDER THE X-RAY RADIATION

Yu. V. Peretiatko, N. O. Sybirna

Ivan Franko Lviv National University, Ukraine;
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Arginine takes part in many metabolic cell processes. It is not only involved in the dynamic cycle of interconversion with prolin and glutamine but also serves as a precursor for protein, nitric oxide, creatine, polyamines, agmatine and urea synthesis. Particularities of arginase and NO-synthase pathways of L-arginine conversion under the X ray radiation in the leucocytes – radiosensitive cells of peripheral blood, under the per os administration of L-arginine and L-NAME (NG-nitro-L-arginine methyl ester) to rats were detected. It was shown that both L-arginine (arginase and NO-synthase main substrate) and L NAME (nonspecific inhibitor of NO-synthase) had a positive correct influence on the organism in case of decreasing of NO overproduction under the X-ray radiation.

Key words: arginase, L-arginine, leucocytes, nitric oxide, NO-synthase, plasma.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal