Journal archive > 2009 > N 2 March-April

EFFECT OF 17 -ESTRADIOL ON mRNA EXPRESSION OF PROAPOPTOTIC PROTEIN BAX
AND DNA FRAGMENTATION LEVEL IN HUMAN ADRENAL CORTEX

M. D. Tronko1, O. I. Kovzun1, E. M. Grinchenko2, А. S. Mikosha1

1State Institution «Komisarenko Institute of Endocrinology & Metabolism, Academy of Medical Sciences of Ukraine», Kyiv;
2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

The effect of 17?-estradiol on the change of proapoptotic protein Bax mRNA level and DNA laddering in human adrenal cortex tissue was studied. The adding of 17?-estradiol to incubation medium caused a decrease of the proapoptotic protein Bax mRNA level in adrenocorticocytes by 22% in comparison with control. Hormone influence decreases the DNA fragmentation by 50%. The obtained data suggest that 17?-estradiol caused a significant antiapoptotic effect in human adrenal cortex.

Key words: adrenal cortex, estradiol, Bax, DNA fragmentation.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal