Journal archive > 2009 > N 1 January-February

CHANGES OF LIPID COMPONENTS RATIO IN THE RAT BILE
AFTER APPLYING BOMBESIN NEUROPEPTIDE

O. F. Moroz1, S. P. Veselsky2, T. P. Lyashchenko1, N. E. Nuryshchenko2

1Human and Animal Physiology Department, Biological Faculty, Taras Shevchenko Kyiv National University, Ukraine;
2Academician Petro Bogach Scientific-Research Institute of Physiology Biological Faculty Taras Shevchenko Kyiv National University, Ukraine;
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Changes of lipid components ratio in the rat bile after bombesin neuropeptide infusion (1 µg per 100 g of body weight) were studied in the acute experiment using the thin-layer chromatography. The cholates-to-cholesterol, phospholipids-to-cholesterol, cholesterol-to its esters ratios and also the potent cholesterol crystallization index were calculated and analyzed. Obtained data indicate that bombesin takes influence on the colloidal parameters of bile enhancing the secretion of phospholipids, cholesterol and its esters and free fatty acids. The peptide also intensifies cholesterol etherification and improves the colloidal stability of bile. After bombesin application the potential ability of cholesterol to crystallization remains at normal rate indicating that the useful balance of micelle forming elements is unaffected, that prevents from the development of gallstone disease.

Key words: bile, bombesin, phospholipids, cholesterol, bile ratios.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal