D. О. Melnychuk1, S. V. Khyzhnyak2, V. A. Grishchenko1, O. O. Kysil2, V. M. Voitsitsky2
Structural and dynamical state of the apical and mitochondrial membranes of enterocytes of the rat small intestine under experimental enteric pathology conditions have been investigated. The modifications of structural and dynamical features of membranes at the use of BAA FLP-MD have been shown. The similarities arising in the versatile destructive changes of membranes are as follows: modification of the lipid phase structure of the membrane, changes in dynamical properties of membrane components and topography, disorders of hydrophobic protein-lipid interactions, conformational changes of protein molecules etc. The differences in correction conditions of the revealed changes of the apical and mitochondrial membranes when using BAA FLP-MD were shown, that is determined by pecularities of the structural and functional features of these membranes.
Key words: enteric pathology, BAA FLP-MD, apical and mitochondrial membranes, the structure of membranes, fluorescent probes.
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