Journal archive > 2009 > N 1 January-February

PECULIARITIES OF SERUM GLYCOPROTEINS FRACTION
COMPOSITION OF RAT BLOOD SERUM AT GUERIN’S CARCINOMA
DEVELOPMENT UNDER DIFFERENT VITAMIN A PROVISION

M. M. Marchenko, I. O. Shmarakov, M. V. Pasajljuk

Fed’kovych Chernivtsy National University, Ukraine;

The most substantial change in the ratio between glycoprotein fractions distributing in the blood serum of rat under conditions of different vitamin A provision (0.50-0.70 µmol/L) are observed; they are characteristic of ?-globulin, haptoglobin and alpha 1-acid glycoprotein; the intensity of colouring of their bars decreases on serum electrophoregrammes. At the same time, the decline of intensity of bar coloration of ceruloplasmin fraction takes place under the conditions of middle vitamin A deficiency (0.35-0.50 µmol/L) while that of transferrin takes place at marginal A-deficient state (? 0.35 µmol/L). In latent and logarithmic periods of Guerin’s carcinoma growth, regardless of conditions of differentt vitamin A provision, the intensity of bars colouring, on electrophoregrammes, which correspond to immunoglobulin, haptoglobin, ceruloplasmin ?2-мacroglobulin, alpha 1-acid glycoprotein and ?1-antytrypsyn, increases. In a stationary period of tumour growth a decrease of coloration intensity of ?- and ?2-globulin fractions is observed.

Key words: vitamin A, vitamin A-deficiency, hypervitaminosis, glycoproteins, Guerin’s carcinoma.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal