Journal archive > 2009 > N 1 January-February

INFLUENCE OF HYDROGEN SULFIDE, DITHIONITE, SULFITE, THIOSULFATE
AND SULFATE ANIONS ON HUMAN PLATELET AGGREGATION

N. V. Zaichko1,2, O. O. Pentiuk2

1Ukrainian State Scientific Research Institute of Invalid Rehabilitation, Vinnytsya;
2Vinnytsya Pirohov National Medical University, Ukraine;
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The influence of hydrogen sulfide, dithionite, sulfite, thiosulfate, and sulfate anions on human platelet aggregation was investigated in vitro. It was established that sulfite, thiosulfate, and sulfate did not influence the platelet aggregation induced by ADP, collagen, or epinephrine in the concentrations range 10-1000 µМ. Hydrogen sulfide and dithionite inhibited platelet aggregation induced by ADP or collagen in a dose-dependent manner. The action of hydrogen sulfide began in concentration of 100 µМ and the action of dithionite began in concentration of 1000?µМ. They did not influence epinephrine-induced platelet aggregation.

Key words: platelet, aggregation, hydrogen sulfide, dithionite.

The original article in Ukrainian is available for download in PDF format.

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