Journal archive > 2009 > N 1 January-February

ACTIVITY OF ALDEHYDE SCAVENGER ENZYMES IN THE HEART OF RATS
OF DIFFERENT AGE DURING IMMOBILIZED STRESS

E. R. Grabovetskaya1, V. V. Davydov2

1Karazin National University, Kharkov, Ukraine;
2S. I. Institute of Children and Adolescent Health Care, Academy of Medical Sciences of Ukraine, Kharkov;

This study was made to determine the activity of aldehyde scavenger enzymes in the heart’s postmitochondrial fraction of rats of different age during immobilization stress. Our study demonstrated, that immobilization of 1.5-, 2- and 12 month rats was accompanied by inhibiting activity of aldehyde dehydrogenase and aldehyde reductase. At the same time we observed an increase in glutathione transferase activity in immobilized 1.5-month-old rats and that in reductase activity in 24-month-old rats. The revealed changes can lead to a decrease in the rate of endogenous aldehyde utilization in the heart during stress at puberty.

Key words: myocardium, ontogenesis, stress, aldehyde, aldehyde dehydrogenase, aldehyde reductase, glutathione transferase.

The original article in Russian is available for download in PDF format.

© The Ukrainian Biochemical Journal