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Journal archive > 2008 > N 6 November-December

THE INFLUENCE OF LECTINS ON?SOME REPAIR PROCESSES IN?MAMMALIAN CELLS IN VITRO

V. V. Lylo, O. O. Piven’, K. V. Serebryakova, L. L. Macewicz, L. L. Lukash

Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kyiv;
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The influence of plant lectins on primary DNA damage repair and on expression of repair enzyme alkylguanine-DNA alkyltransferase (MGMT) in mammalian cells in vitro has been investigated. Those lectins have been shown to modify DNA damage repair process, and to induce the MGMT expression increasing its level in the used model system.

Key words: O6-alkylguanine-DNA alkyltransferase, expression, lectins, cell culture, Western­ Blotting-analysis, DNA damage and repair, comet assay.

The original article in Russian is available for download in PDF format.

© The Ukrainian Biochemical Journal