THE INFLUENCE OF LECTINS ON?SOME REPAIR PROCESSES IN?MAMMALIAN CELLS IN VITRO
V. V. Lylo, O. O. Piven’, K. V. Serebryakova, L. L. Macewicz, L. L. Lukash
The influence of plant lectins on primary DNA damage repair and on expression of repair enzyme alkylguanine-DNA alkyltransferase (MGMT) in mammalian cells in vitro has been investigated. Those lectins have been shown to modify DNA damage repair process, and to induce the MGMT expression increasing its level in the used model system.
Key words: O6-alkylguanine-DNA alkyltransferase, expression, lectins, cell culture, Western Blotting-analysis, DNA damage and repair, comet assay.
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