title en

 
ANTIOXIDANT AND MEMBRANOTROPIC ACTION OF MONOCHROMANES
AND TRIMETHYLPHENOLS DERIVATIVES IN VITRO

 

Yu. I. Gubsky, А. G. Goryushko, N.V.Litvinova, V. P. Makovetsky, T.N.Kurapova, О. V. Aphanasenko, A.N.Velichko

Institute of Pharmacology and Toxicology, AMS of Ukraine, Kyiv;
e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Using some biochemical and physico-chemical methods of investigation, antioxidant activity and membrane protective effect of derivatives of monochromanes and trimethylphenols has been studied most active inhibitors of lipoperoxidation and the compounds capacity to structural modification of properties of the surface and hydrophobic zones of phospholipids bilayer in membranes of endoplasmic reticulum of the liver cells of rats have been determined.

Key words: membranes, endoplasmic reticulum, fluorescent probes, antioxidants, monochromanes, trimethylphenols.

The original article in Ukrainian is available for download in PDF format.

© The Ukrainian Biochemical Journal