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Journal archive > 2008 > N 5 September-October

INFLUENCE OF LONG-TERM JOINT ?-RADIATION AND ETHANOL
ON CYTOCHROME P450 2E1 EXPRESSION IN MICE LIVER

O. V. Maksymchuk, V. I. Bobyk, L. L. Sidorik, M. O. Chaschyn

Institute of Molecular Biology and Genetic, National Academy of Sciences of Ukraine, Kyiv;
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The effect of continuous single and combined influence of exogenous stress factors (ethanol and low intensity ?-radiation) on cytochrome P450 2E1 (1.14.14.1) expression in mice liver was studied. The chronic ethanol intake induced Cyp2E1 protein expression but not increased Cyp2e1 mRNA level. The first week of continuous­ combined influence of ethanol and gamma-irradiation was characterized by the increase of Cyp2E1 protein level, that was back to normal on second week. A small decrease of this index was observed at the end of the fifth week. The changes of Cyp2E1 protein amount accompanied the decrease of Cyp2e1 mRNA level. 

Key words: Cytochrome P450 2E1, ?-irradiation, ethanol, Cyp2e1 mRNA and protein expression, oxidative stress.

The original article in Ukrainian is available for download in PDF format.

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