T. A. Tkachenko
It was shown that the increase of lead content in the blood, liver, placenta of female rats, rat embryo and embryo’s liver (by 80.4; 30.9; 26.8; 18.2 and 22.7%, respectively) of rats poisoned by lead causes pH decrease in blood, reduction of НСО3- concentration, content of general СО2, level of pСО2 and рО2, that evidences for development of subcompensated metabolic acidosis. It was determined, that the poisoning of pregnant rats causes deep metabolic acidosis and hypoxia in their organisms that can result in the prenatal death of fetus.
Key words: lead acetate, acid-base state, metabolic acidosis, shifts of buffer telae.
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